Animal Health Solutions

PROIN ER™ (phenylpropanolamine hydrochloride extended-release tablets) For complete prescribing information, see full package insert. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. It is a violation of Federal Law to use this product other than as directed in the labeling. Indication: For the control of urinary incontinence due to urethral sphincter hypotonus in dogs. Warnings: Not for human use. Keep out of reach of children. Consult a physician in case of accidental ingestion by humans. Keep PROIN ER in a secured location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Precautions: PROIN ER may mask signs of incontinence due to urinary tract infection. Proin ER hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water. The safe use of PROIN ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating. Adverse reactions: the most common clinical abnormalities documented were emesis, body weight loss, hypertension, diarrhea, proteinuria, tachycardia, lethargy, decreased appetite, urinary tract infection and elevated alkaline phosphatase and/or alanine aminotransferase. There were an additional 21 dogs enrolled with diarrhea, or decreased appetite which improved or resolved prior to the Day 21 visit. Four deaths occurred during the study. One dog was euthanized for pulmonary metastasis and one dog for poor quality of life due to hindlimb weakness. One dog had emesis and died at home; upon necropsy a foreign body was present in the small intestine. The fourth dog had been treated for a urinary tract infection three weeks prior to sudden death of undetermined cause. In this study, 119 dogs (113 spayed females and 6 neutered males, aged 1-16 years and weighing 4.9-81.8 kg) who were considered well controlled for signs of urinary incontinence (UI) while receiving PROIN Chewable Tablets for at least 30 days prior to study start were enrolled in the study. Of these dogs, 104 period (Day -7 through Day -1). After the baseline period, the owner transitioned to administration of PROIN ER once a day, at the labeled dose, and recorded urinary accidents for 28 days. The primary variable was the ratio of average daily incidence of UI during the 7 days preceding the Day 28 clinic visit compared secondary outcome variable was owner assessment of the control of UI at the end of the 28 day study period. The owner assessment was "improved" for 13 (12.5%) dogs, "stayed the same" for 90 (86.5%) dogs and "worsened" for 1 dog (1%). Animal Safety: See full product insert for further details. To obtain full product information please call 800-874-9764 or visit Proin-ER.com. Approved by FDA under NADA #141-517. PROIN ER is a trademark of Pegasus Laboratories, Inc. Dosage and Administration: For use in dogs only. The total recommended dosage range is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily. Administer with food. Do not split or crush tablets. Storage: Store at 20-25°C (68-77°F). WARNINGS: NOT FOR USE IN HUMANS. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN. Streamline client payments with integrated payment processing ©2024 Covetrus, Inc. All rights reserved. No copying without consent. COVETRUS ® PAY MENTS Covetrus Payments shortens check-out time, simplifies reconciliation and makes your client payment experience more convenient than ever with best-in-class devices and seamless integration. Maintain strong client relationships with unrivaled payment convenience. Optimize your business with one strategic payments partner. Stay secure and up to date automatically with remote device upgrades. Grow you practice as technology advances – now offering Covetrus ® Pulse ™ integration with TriPOS Cloud for faster setup and installation. To learn more, visit cvet.co/payment-processing

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