Animal Health Solutions

Until something more advanced came along. IMPORTANT SAFET Y INFORMATION: For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contac t a physician immediately. The most commonly repor ted side effec ts were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enz yme elevations, kidney failure, blood in urine and urine retention have been repor ted. In some cases death, including euthanasia has been repor ted. Sudden death was sometimes preceded by vocalization or collapse. Instances of dogs chewing through closed vials of PROIN® and eating the vial contents have been repor ted, in some cases resulting in overdose. Keep the produc t in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN® Chewable Tablets or PROIN ER™ tablets. Contac t your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN® Chewable Tablets or PROIN ER™ tablets. PROIN® and PROIN ER™ may cause elevated blood pressure and should be used with caution in dogs with pre - existing hear t disease, high blood pressure, liver disease, kidney insufficienc y, diabetes, glaucoma, and other conditions associated with high blood pressure. D ogs may transition from PROIN® Chewable Tablets to PROIN ER™ without a break in administration. However, do not alternate PROIN ER™ with PROIN® Chewable Tablets because the effec tiveness and safet y of interchangeable use have not been evaluated. The safe use of PROIN® and PROIN ER™ in dogs used for breeding purposes, during pregnanc y or in lac tating bitches, has not been evaluated. Contac t your veterinarian if you notice restlessness or irritabilit y, loss of appetite, the incontinence persists or worsens, or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions or visit prnpharmacal.com. *Consumer D og O wner sur vey conduc ted by PRN Pharmacal, D ecember 2022 | ©2024 PRN Pharmacal, Inc. All rights reser ved. PROIN ER™ Approved by FDA under NADA # 141-517 Learn more at proin-er.com UPGRADE YOUR CANINE UI TREATMENT TO TODAY'S TECHNOLOGY. ONCE-DAILY CONSISTENT PREFERRED TRUSTED Convenient once-daily dosing can help improve client compliance. Patented extended-release technology decreases fluctuation in blood levels throughout the day. 97% of dog owners prefer the once-daily dosing of PROIN ER. ™* The only once-a-day, FDA-approved medication for urinary incontinence (UI) due to urethral sphincter hypotonus in dogs.

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