18 Pharmaceutical Technology
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Trends in Manufacturing eBook May 2024 PharmTech.com
MULTIMODAL
• Flexibilit y for market changes . Con su mer
preferences a nd m a rket t rend s ca n ch a nge
rapidly. A multimodal manufacturing facility
equips an organization with the agility to swiftly
adapt to shifting demands and evolving market
landscapes.
• Supply chain resilience. Having multiple man-
ufacturing options in-house can enhance supply
chain resilience and minimize potential risks
associated with timing, especially for certain
autologous cell therapy products. If one manufac-
turing process faces disruptions or supply chain
challenges, pivoting to another mode ensures a
consistent supply of products.
• Innovation and product dif ferentiation. A
multimodal facility allows for the integration
of i n n o v a t i v e m a nu f a c t u r i n g t e c h n i q u e s ,
which can lead to the development of unique
and differentiated products. This can provide
a p o t e n t i a l c om p e t i t i v e e d g e a n d a t t r a c t
customers seek ing in novat ive products a nd
manufacturing capabilities.
This facility design approach must focus on the
specific facility attributes previously discussed. The
following example illustrates a few layout scenarios.
Oligo. For an oligo manufacturing area (Figure 2), a
key concern as mentioned is the use of solvents. This
points to a layout where key equipment will be placed
FIGURE . Illustration shows general oligonucleotide layout. MFG is manufacturing.
mRNA is messenger RNA. LNP is lipid nanoparticle. CNC/NC is controlled non-
classified/non-classified.
