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Tablets & Capsules April 2015 21 Figure 2 Effect of spray rate and nozzle-to-bed distance on tablet assay 106 104 102 100 98 96 94 Spray rate (g/min) Nozzle-to-bed distance (cm) Note: Pan speed = 14 rpm and atomizing-air pressure = 1.4 bar Assay (%) 3 16 15 13 12 11 10 14 4 6 7 8 9 5 Figure 3 Effect of spray rate and atomizing-air pressure on tablet assay (%) 102 100 98 96 1.2 1.3 1.4 1.5 1.6 9 8 7 6 5 4 3 Atomizing-air pressure (bar) Spray rate (g/min) Note: Pan speed = 14 rpm and nozzle-to-bed distance = 13 cm Figure 4 Effect of coating process variables on RSD of content uniformity (half-normal plot) Nozzle-to-bed distance Spray rate Atomizing-air pressure Pan speed 0.00 0.33 0.65 0.98 1.31 99 95 90 80 70 50 30 20 10 0 Standardized effect Probability (%) Note: Pan speed = 14 rpm and nozzle-to-bed distance = 13 cm Positive effects Negative effects For more information: compactionsimulation.com An annual event that combines industrial and academic expertise to understand how compaction simulation can: • Support formulation decisions • Optimize processing • Streamline development • Promote Quality by Design as a complementary tool to on-press experimentation CSF is an open assembly where people from industry and academia exchange ideas and experiences to advance the science of powder compaction simulation. Poster submission deadline is May 15. Compaction Simulation Forum June 16-17, 2015 University of Copenhagen Copenhagen, Denmark