Tablets & Capsules

TC0317

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44 March 2017 Tablets & Capsules a laser-based measurement system can help with this for- mulation work. Tablet research. The SF/porosity of tablets is one of the most important factors governing the disintegration and dissolution rates of tablets. Few researchers use tablet SF data, however, because of the time and effort that routine SF measurements using traditional methods require. A laser-based system that takes multiple, unat- tended measurements can increase efficiency and make SF measurements of tablets more routine. An in-house study demonstrated the reproducibility of tablet measurements. The study used 16 generic aspirin tablets, each of which was manually loaded 16 times into a 16-position "nest," and a total of 16 unattended "mea- surement runs" were made. The results indicate that, for the 16 measurements of each tablet, the standard devia- tion of the SF did not exceed 0.004 on any tablet, and the average standard deviation was 0.0024. By demonstrating its ability to make unattended, very repeatable, high- resolution tablet SF measurements, a laser-based system appears well suited to improving tablet research and to doing so more quickly than traditional techniques. T&C References 1. Hancock, B.C., Colvin, J.T., Mullarney, M.P., and Zinchuk, A.V. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets. Pharmaceutical Technology, 63-80, April 2003. 2. Allesø, M., Holm, R., and Holm, P., Roller com- paction scale-up using roll width as scale factor and laser- based determined ribbon porosity as critical material attribute. Eur J Pharm Sci 87, 69-78, 2016. 3. Iyer, R.M., Hegde, S., Singhal, D., and Malick. W. A novel approach to determine solid fraction using a laser-based direct volume measurement device. Pharm Dev Technol 19(5), 577-582, 2014. 4. Iyer, R.M., Hegde, S., DiNuzio, J., Singhal, D., and Malick. W. The impact of roller compaction and tablet compression on physicomechanical properties of phar- maceutical excipients. Pharm Dev Technol 19(5), 583- 592, 2014. 5. The complete dataset is available at www.solidfrac tion.com. Terry Chriss, PhD, is president of Solid Fraction Measurement Systems, 90 Main Street, Unit 108B, Centerbrook, CT 06409. Tel. 888 770 7498, ext. 521. Website: www.solidfraction.com.

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