Issue link: https://www.e-digitaleditions.com/i/1244583
Tablets & Capsules May 2020 35 References 1. Purushottam R. Patil, Vaibhav D. Bobade, Pankaj L. Sawant, and Rajendra P. Marathe, "Emerging trends in compression coated tablet dosage forms: A review," International Journal of Pharmaceutical Sciences and Research, March 2016. 2. "Excipients in Pharmaceuticals," BCC Research, March 2016. 3. Chapter 1174, Powder Flow, USP-NF. 4. B. van Veen, G.K. Bolhuis, Y.S. Wu, K. Zuurman, and H.W. Frijlink, "Compaction mechanism and tablet strength of unlubricated and lubri- cated (silicified) microcrystalline cel- lulose," European Journal of Pharmaceutics and Biopharmaceutics, 2005, Vol. 59, No. 1, pages 133-8. 5 . S t e p h e n E d g e , U r s u l a J . Potter, D. Fraser Steele, Michael J. Tobyn, Ansong Chen, and John N. Staniforth, "The location of silicon dioxide in silicified microcrystalline cellulose," Pharmacy and Pharmacology Communications, 1999, Vol. 5, No. 6, pages 371-6. that a co-processed excipient such as SMCC lends itself to improved flow and better compactibility during compression, which results in lower tablet weight variation and better content uniformity. These traits allow formulators to produce a robust tablet as well as facilitate DC or alternative continuous manufacturing processes. As the trend toward continuous pharma manufacturing continues, it is essential that manufacturers are equipped with excipients that are optimized for such operations, since incorporating the incorrect excipient can cause a manufacturing process to malfunction. This study shows that co-processed excipients, such as SMCC, can help solve many con- tinuous manufacturing challenges by improving flow, compactibility, and tablet tensile strength. Formulators should consider that these attributes may make co-processed excipients such as SMCC beneficial in pro- cesses besides DC tableting as well, such as multi-particulate systems or dry granulation. T&C 6. Mira Jivraj, Luigi G. Martini, and Carol M. Thomson, "An over- view of the different excipients useful for the direct compression of tab- lets," Pharmaceutical Science & Technology Today, 2000, Vol. 3, No. 2, pages 58-63. Michael Baumann is global strategic marketing manager, immediate-release pharmaceutical dosage forms; Vinay Muley is India leader, technology & innovation, pharmaceutical solutions; Fernanda Onofre is Americas regional applications leader, pharmaceutical solutions; and Juergen Engelhardt is technical fellow, pharmaceutical solu- tions, at DuPont Nutrition & Biosci- ences. For questions or comments about this article, please contact Lindsay Tor- riero, global communications leader, pharmaceutical solutions, DuPont Nutrition & Biosciences (lindsay.torri ero@dupont.com).