Inhalation

INH0622

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18 June 2022 Inhalation 27. Bass K, Farkas D, Hassan A, Bonasera S, Hin- dle M and Longest PW: High-efficiency dry powder aerosol delivery to children: Review and applica- tion of new technologies. Journal of Aerosol Science 2021,153:105692. 28. Bass K, Boc S, Hindle M, Dodson K and Longest W: High-efficiency nose-to-lung aerosol delivery in an infant: Development of a validated computational fluid dynamics method. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2019,32:132-148. 29. Kimbell JS and Subramaniam RP: Use of com- putational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhalation Toxi- cology 2001,13:325-334. 30. Walenga RL and Longest PW: Current inhal- ers deliver very small doses to the lower tracheo- bronchial airways: Assessment of healthy and constricted lungs. Journal of Pharmaceutical Sciences 2016,105:147-159. 31. Longest PW, Tian G, Khajeh-Hosseini-Dalasm N and Hindle M: Validating whole-lung CFD pre- dictions of DPI aerosol deposition at multiple flow rates. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2016,29:461-481. 32. Kolanjiyil AV and Kleinstreuer C: Compu- tational analysis of aerosol-dynamics in a human whole-lung airway model. Journal of Aerosol Science 2017,114:301-316. 33. Mahian O, Kolsi L, Amani M, Estellé P, Ahmadi G, Kleinstreuer C, Marshall JS, Siavashi M, Taylor RA, Niazmand H, Wongwises S, Hayat T, Kolanjiyil A, Kasaeian A and Pop I: Recent advances in model- ing and simulation of nanofluid flows-Part I: Funda- mentals and theory. Physics Reports 2019,790:1-48. 34. Cherobin GB, Voegels RL, Gebrim EM and Garcia GJ: Sensitivity of nasal airflow variables com- puted via computational fluid dynamics to the com- puted tomography segmentation threshold. PLOS One 2018,13:e0207178. 35. Kolanjiyil AV, Alfaifi A, Aladwani G, Golshahi L and Longest, W: Importance of spray–wall interac- tion and post-deposition liquid motion in the trans- port and delivery of pharmaceutical nasal sprays. Pharmaceutics 2022,14(5):956. 36. Hosseini S, Schuman TA, Walenga R, Wilkins Jr JV, Babiskin A and Golshahi L: Use of anatomically- accurate 3-dimensional nasal airway models of adult human subjects in a novel methodology to identify and evaluate the internal nasal valve. Computers in Biology and Medicine 2020,123:103896. Arun V. Kolanjiyil, PhD, is a postdoctoral research associate and Worth Longest, PhD, is a Professor in the Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, Vir- ginia, US, pwlongest@vcu.edu, www.sites.google.com/ vcu.edu/longest-lab/home. delivery using multiple anatomical nasal replicas of adult human subjects and two nasal sprays. Interna- tional Journal of Pharmaceutics 2021,593: 120103. 15. Newman SP, Pitcairn GR and Dalby RN: Drug delivery to the nasal cavity: In vitro and in vivo assess- ment. Critical Reviews™ in erapeutic Drug Carrier Systems 2004,21:21-66. 16. Longest PW, Bass K, Dutta R, Rani V, omas ML, El-Achwah A and Hindle M: Use of computa- tional fluid dynamics deposition modeling in respira- tory drug delivery. Expert Opinion on Drug Delivery 2019,16:7-26. 17. Walenga RL, Babiskin AH and Zhao L: In sil- ico methods for development of generic drug– device combination orally inhaled drug products. CPT: Pharmacometrics & Systems Pharmacology 2019,8:359-370. 18. Kiaee M, Wachtel H, Noga ML, Martin AR and Finlay W: An idealized geometry that mimics average nasal spray deposition in adults: A compu- tational study. Computers in Biology and Medicine 2019,107:206-217. 19. Versteeg HK and Malalasekera W. An introduc- tion to computational fluid dynamics: e finite vol- ume method, Prentice Hall, New York, 2007. 20. Tu J, Inthavong K and Ahmadi G. Computa- tional fluid and particle dynamics in the human respiratory system, Springer, New York, 2012. 21. Longest PW and Holbrook LT: In silico models of aerosol delivery to the respiratory tract - Devel- opment and applications. Advanced Drug Delivery Reviews 2012,64:296-311. 22. Wong W, Fletcher DF, Traini D, Chan HK and Young PM: e use of computational approaches in inhaler development. Advanced Drug Delivery Reviews 2012,64:312-322. 23. Feng Y, Hayati H, Bates AJ, Walter K, Matthias L, Odo B, Ramiro O and Gerda K. Clinical CFD applications 2. Clinical and biomedical engineering in the human nose, Springer, New York, 2021. 24. Tong Z, Zhong W, Yu A, Chan H-K and Yang R: CFD–DEM investigation of the effect of agglomerate– agglomerate collision on dry pow- der aerosolisation. Journal of Aerosol Science 2016,92:109-121. 25. Saikat B, Holbrook LT, Kathryn K, Olulade F, Wu J, Burke A, Langworthy BW, Zainab F, Mam- dani M and Bennett WD: Numerical evaluation of spray position for improved nasal drug delivery. Sci- entific Reports (Nature Publisher Group) 2020,10. 26. Xi J, Wang Z, Nevorski D, White T and Zhou Y: Nasal and olfactory deposition with normal and bidirectional intranasal delivery techniques: In vitro tests and numerical simulations. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2017,30:118-131.

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