Inhalation

INH0822

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Inhalation August 2022 19 7. Dehaan WH, Finlay WH: Predicting extratho- racic deposition from dry powder inhalers. Journal of Aerosol Science 2004, 35(3):309-331. 8. Myszko M, Tips: Getting started with CFD, Inha- lation 2008, 2(3):16-17. 9. Patterson B, Modeling paradigms for orally inhaled drugs, Inhalation 2015, 9(4):27-28. 10. Ruzycki C, Javaheri E, Finlay W: e use of com- putational fluid dynamics in inhaler design. Expert Opinion on Drug Delivery 2013, 10(3):307-323. 11. Wong W, Fletcher D, Traini D, Chan H-K, Young P: e use of computational approaches in inhaler development. Advanced Drug Delivery Reviews 2012, 64(4):312-322. 12. Longest PW, Holbrook LT: In silico models of aerosol delivery to the respiratory tract—Develop- ment and applications. Advanced Drug Delivery Reviews 2012, 64(4):296-311. 13. Gavtash B, Versteeg HK, Hargrave G, Myatt B, et al.: A model of transient internal flow and atomi- zation of propellant/ethanol mixtures in pressurized metered dose inhalers (pMDI). Aerosol Science and Technology 2018, 52(5):494-504. 14. Duke DJ, Nguyen DT, Scott HN, Kusangaya AJ, et al.: Combining modelling with advanced experimental techniques to optimize formulation and nozzle design for low GWP pMDIs. In Respi- ratory Drug Delivery 2021. Volume 1. Edited by Dalby RN, Peart J, Suman JD, Young PM, Traini D. DHI Publishing; River Grove, IL, US: 2021:35-44. 15. Myatt B, Newton R, Lewis D, Church T, et al.: PDA and high speed image analysis of HFA/ethanol pMDI aerosols: New findings. In Drug Delivery to the Lungs 2015. e Aerosol Society. Bristol, UK: 2015:26. 16. Mason-Smith N, Duke DJ, Kastengren AL, Edgington- Mitchell D, et al.: High-speed X-ray imaging of pressurized metered-dose inhaler sprays with variable ethanol content. In ILASS—Asia 2017. 17. McKiernan A, omas T, Duignan C: HFA-152a inhaler dose release. In Drug Delivery to the Lungs 2021. e Aerosol Society. Bristol, UK: 2021:32. 18. Longest PW, Farkas D: Development of a new inhaler for high-efficiency dispersion of spray-dried powders using computational fluid dynamics (CFD) modeling. e AAPS Journal 2019, 21:25. 19. Xi J, Yuan JE, Yang M, Si X, et al.: Parametric study on mouth–throat geometrical factors on depo- sition of orally inhaled aerosols. Journal of Aerosol Science 2016, 99:94-106. 20. Gavtash B, Versteeg HK, Hargrave G, Myatt B, et al.: Multi-physics theoretical approach to predict pMDI spray characteristics. In Drug Delivery to the Lungs 2016. e Aerosol Society. Bristol, UK: 2016:27. 21. Camm J: Propellant and formulation properties for next-generation pMDIs: Measurement, represen- tation and prediction, Inhalation 2021, 15(5):21-27. 22. Camm J, Versteeg HK: A thermodynamic frame- work to predict thermophysical properties that con- trol pMDI aerosol generation. In Respiratory Drug Delivery 2021. Volume 1. Edited by Dalby RN, Peart J, Suman JD, Young PM, Traini D. DHI Pub- lishing; River Grove, IL, US: 2021:27-34. 23. De Backer J: Functional respiratory imaging (FRI): An alternative to pulmonary function tests (PFTs), Inhalation 2016, 10(5):17-22. 24. Steinman D: Image-based computational fluid dynamics modeling in realistic arterial geometries. Annals of Biomedical Engineering 2002, 30:483-497. 25. Miraucourt O, Génevaux O, Szopos M, iriet M, et al.: 3D CFD in complex vascular systems: A case study. In Biomedical Simulation, 6th Interna- tional Symposium, ISBMS 2014, Edited by Fer- nando Bello Stéphane Cotin. Springer: Heidelberg, Germany: 2014. 26. Shaw C: Penetration enhancers and mucoadhe- sives in liquid nasal spray formulations, Inhalation 2021, 15(5):11-17. 27. Mooney K: A computational study of non-New- tonian droplet dynamics. PhD esis, University of Massachusetts Amherst, 2016. 28. Rodríguez-Rivero C, Nogareda J, Martín M, Martín del Valle EM, et al.: CFD modeling and its validation of non-Newtonian fluid flow in a micro- particle production process using fan jet nozzles. Powder Technology 2013, 246:617-624. 29. Dukowicz JK: A particle-fluid numerical model for liquid sprays. Journal of Computational Physics 1980, 35:229-253. 30. Longest PW, Vinchurkar S: Effects of mesh style and grid convergence on particle deposition in bifur- cating airway models with comparisons to experi- mental data. Medical Engineering & Physics 2007, 29:350-366. 31. Bass K, Longest PW: Recommendations for sim- ulating microparticle deposition at conditions similar to the upper airways with two-equation turbulence models. Journal of Aerosol Science 2018, 119:31-50. Joseph Camm, PhD, is a Lecturer in Mechanical Engi- neering, School of Engineering, University of Liverpool, UK, www.linkedin.com/in/joseph-camm-45830539.

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