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20 February 2023 Inhalation 51. Sécher, T., et al., Correlation and clinical rele- vance of animal models for inhaled pharmaceuticals and biopharmaceuticals. Adv Drug Deliv Rev, 2020. 167: p. 148-169. 52. Guillon, A., et al., Insights on animal models to investigate inhalation therapy: Relevance for biother- apeutics. Int J Pharm, 2018. 536(1): p. 116-126. 53. Ong, H.X., et al., e effects of mannitol on the transport of ciprofloxacin across respiratory epithelia. Mol Pharm, 2013. 10(8): p. 2915-2924. 54. Lancaster, M.A., et al., Organogenesis in a dish: Modeling development and disease using organoid technologies. Science, 2014. 345(6194): p. 1247125. 55. Ramani, S., et al., Human organoid cultures: Transformative new tools for human virus studies. Curr Opin Virol, 2018. 29: p. 79-86. 56. Rijal, G., et al., A versatile 3D tissue matrix scaf- fold system for tumor modeling and drug screening. Sci Adv, 2017. 3(9): p. e1700764. 57. Bhatia, S.N., et al., Microfluidic organs-on-chips. Nat Biotechnol, 2014. 32(8): p. 760-772. 58. Lee, J., et al., In vitro toxicity testing of nanopar- ticles in 3D cell culture. Small, 2009. 5(10): p. 1213-1221. 59. Gholizadeh, H., et al., Development of a micro- fluidic nose-on-a-chip for real-time nasal drug assessment. Respiratory Drug Delivery 2020, 2020. Virginia Commonwealth University. 60. Ye, Z., et al., An adaptable microreactor to inves- tigate the influence of interfaces on Pseudomonas aeruginosa biofilm growth. Appl Microbiol Biotech- nol, 2022. 106(3): p. 1067-1077. 61. Zhang, Y., et al., Understanding the effects of aerodynamic and hydrodynamic shear forces on Pseudomonas aeruginosa biofilm growth. Biotechnol Bioeng, 2022. 62. Huh, D., et al., Reconstituting organ-level lung functions on a chip. Science, 2010. 328(5986): p. 1662-1668. 63. Rangaraj, N., et al., Insight into pulmonary drug delivery: Mechanism of drug deposition to device characterization and regulatory requirements. Pulm Pharmacol er, 2019. 54: p. 1-21. 64. Taki, M., et al., Aerodynamic deposition of com- bination dry powder inhaler formulations in vitro: A comparison of three impactors. Int J Pharm, 2010. 388(1-2): p. 40-51. 65. Zhang, Y., et al., Nanoparticle delivery platforms for RNAi therapeutics targeting COVID-19 disease in the respiratory tract. Int J Mol Sci, 2022. 23(5) p. 2408. 66. Haghi, M., et al., In vitro cell integrated impac- tor deposition methodology for the study of aero- dynamically relevant size fractions from commercial pressurised metered dose inhalers. Pharm Res, 2014. 31(7): p. 1779-1787. 67. Wong, C.Y.J., et al., Validation of a cell inte- grated next-generation impactor to assess in vitro drug transport of physiologically relevant aerosolised particles. Int J Pharm, 2022. 624: p. 122024. 68. Ong, H.X., et al., Is the cellular uptake of respira- tory aerosols delivered from different devices equiva- lent? Eur J Pharm Biopharm, 2015. 93: p. 320-327. 69. Goers, L., et al., Co-culture systems and technol- ogies: Taking synthetic biology to the next level. J R Soc Interface, 2014. 11(96): p. 20140065. 70. Castellani, S., et al., Human cellular models for the investigation of lung inflammation and mucus production in cystic fibrosis. Anal Cell Pathol, 2018. 2018: p. 3839803. 71. Pant, T., et al., Establishment and characteriza- tion of lung co‐culture spheroids for paclitaxel loaded Eudragit ® RL 100 nanoparticle evaluation. Biotech- nol Prog, 2021. 37(6): p. e3203. 72. Haghi, M., et al., Mono- and cocultures of bron- chial and alveolar epithelial cells respond differently to proinflammatory stimuli and their modulation by salbutamol and budesonide. Mol Pharm, 2015. 12(8): p. 2625-2632. 73. Ong, H.X., et al., Establishment of a lung infec- tion co-culture in vitro model for chronic obstructive pulmonary disease. Respiratory Drug Delivery 2016, 2016. RDD Online. 74. Lehmann, A.D., et al., An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier. Eur J Pharm Bio- pharm, 2011. 77(3): p. 398-406. 75. Costa, A., et al., Triple co-culture of human alve- olar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air- blood barrier. Acta Biomater, 2019. 91: p. 235-247. 76. Schleh, C., et al., Surfactant protein D modulates allergen particle uptake and inflammatory response in a human epithelial airway model. Respir Res, 2012. 13(1): p. 1-10. Juhura Gania Almazi, BSc. (Hons.), PhD, is Lead Sci- entist and Hui Xin Ong, B. Pharm. (Hons.), PhD is Chief Scientific Officer, Ab Initio Pharma, Camper- down, NSW 2050, Australia. Corresponding author: Hui Xin Ong, huixin.ong@ab-initio-pharma.com. ab-initio-pharma.com.