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b-TOCFN_1-9_Masters 1/8/14 10:46 AM Page 2 TABLETS & CAPSULES w w w. t a b l e t s c a p s u l e s . c o m January 2014 Volume 12 Number 1 capsule filling Photo shows Qualicaps twopiece liquid-filled capsules. They are available in gelatin and hypromellose (HPMC) in a variety of sizes and colors, including clear (shown). Plant-based HPMC capsules are kosher- and halal-certified The company also provides automated capsule filling equipment and integrated band-sealing equipment. Custom capsule design and printing are available. Courtesy of Qualicaps, Whitsett, NC. Tel. 800 227 7853. Website: www.qualicaps.com. A rapid vehicle-screening approach for formulating a low-solubility compound into liquid-filled capsules 10 Amol Kheur, Anil Kane, Mohammad Aleem, Maureen McLaughlin, Kiran Kumar Tumbalam, and Shivaprakash Poojary Strategies for improving capsule filling efficiency 16 John Davidson Issue focus: Capsules and capsule filling 20 granulation & drying The ABCs of roller compaction 26 Vic Shulman 30 Granulation and drying: A survey of what's available also in this issue INTERPHEX preview Dissolution testing: A survey of what's available Eye on Excipients 34 36 39 Matthew Knopp 64 Leo Stevens Back Page departments Research news 6 Calendar 44 Markets 6 Supplier news 45 Industry news 8 People news 47 48 Industry innovations 42 Mini case histories and Product reviews Call for posters 44 Spotlight on Nutraceuticals 32A (This section appears four times yearly in issues delivered to our nutraceutical readership.) Tablets &Capsules (ISSN 1549-9928 print; ISSN 1938-9159 online) is published eight times a year in January, March, April, May, July, September, October, and November by CSC Publishing, Inc., 1155 Northland Drive, Saint Paul, MN 55120. Periodicals postage paid at Saint Paul, MN, and additional mailing office. POSTMASTER: Send address changes to Tablets &Capsules, 1155 Northland Drive, Saint Paul, MN 55120.