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C capsules HPMC capsules gain credibility as alternative to gelatin Ken Seufert Meggle USA Kirti Vatsa Beroe This article summarizes the advantages of HPMC capsules over hard gelatin capsules, compares their actual and forecast rates of growth, and documents recent investments in capsule manufacturing by the major suppliers. apsules continue to be a favored drug delivery vehicle for early-stage development of solid oral dosage forms. They offer formulation flexibility, are compatible with various active pharmaceutical ingredient (API) forms, and can expedite clinical evaluation. By 2014, 10 to 15 percent of FDA approved drug prod- ucts were capsule formulations. In 2007, only 5 percent were. Capsules made from gelatin—which is derived from animals—have been the dominant capsule in the pharma- ceutical industry and that will likely continue. Capsules Tablets & Capsules September 2016 41