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46 March 2018 Tablets & Capsules commodity excipients is expected to increase. As shown in Table 3, ACG- Associated Capsules, a supplier of hard gelatin capsule (HGC) hydroxypropyl methylcellulose (HPMC) capsule shells, and Ideal Cures, a supplier of coatings, are the top Indian suppliers by number of manufacturing facilities certified by ExciPact. Expanding export capacity. Excipient suppliers have shown increasing interest in expanding their exports to developed markets. Recent developments include the following: • In 2016, Nitika Pharmaceutical announced plans to build its fourth excipient plant in Nagpur, India, primarily to cater to the export market [6]. allowed DFE to increase its global market share in cellulosic excipients. Table 2 shows the Indian export growth rate from 2015 to 2016 along with the major Indian DMF holders for several common solid oral dosage excipients. The market structure for these excipients is mostly consolidated between US and European suppliers, while Indian suppliers occupy just 5 to 10 percent of the global market share. Out of 62 total ExciPact manufac- turing facilities, 19 percent are in India, and that number is expected to increase over the next several years. As more Indian suppliers achieve ExciPact and GMP certifications, the export of • In 2016, ACG-Associated Capsules received ExciPact certification (indicating compliance with EU and US FDA regulations) for its plant at Dahanu, Maharastra, India [7]. • In 2014, the Controlled Release Alliance between Dow and Colorcon announced the launch of Methocel DC2 in Hyderabad, India. The HPMC product allows pharmaceutical manufac- turers to replace costly wet granulation in matrix tablet production with cost- effective dry granulation and direct compression techniques, reducing manufacturing costs by up to 60 percent and shortening development time [8]. Table 2 Indian export growth rate of common solid oral dosage excipients Excipient Export growth rate (percentage) Major Indian suppliers (US DMF holders) Price US Europe Calcium phosphate (dibasic & tribasic) 6-8 20-25 Sudeep Pharma Hindustan Phosphates India Phosphate Crest Cellulose Not available MCC 5 2 Sigachi DFE Pharma Gujarat Microwax Developed market = US $4-5 per kilogram Emerging market = US $2-3 per kilogram Sodium starch glycolate 6 2 Crest Cellulose Not available Source: Eximpulse, Beroe Analysis Table 3 ExciPact-certified Indian excipient suppliers Supplier Issue date Location Excipient ACG-Associated Capsules 2017 Khandala, Maharashtra HGC shell Pithampur, Madhya Pradesh HGC and HPMC shell Thane, Maharashtra HGC and HPMC shell Ideal Cures 2015 District Anand, Gujarat Methacrylic acid copolymers and dispersions, ethyl acrylate copolymers Jammu, Jammu, & Kashmir Coating Thane, Maharashtra Coating Asha Cellulose 2017 Valsad, Gujarat Ethyl cellulose Sigachi Industries 2017 Dahej, District Bharuch, Gujarat Cellulose Chemfield Cellulose 2016 Nagpur MCC Colorcon Asia 2016 Verna, Goa Pigments, color Sudeep Pharma 2016 Vadodara, Gujarat Dicalcium phosphate, tribasic calcium phosphate, calcium carbonate Vikram Thermo 2015 District Gandhinager, Gujarat Acrylate polymer Source: ExciPact