Tablets & Capsules


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Tablets & Capsules January 2017 15 C capsules How to assess and prevent brittleness of hard gelatin capsules Jnanadeva Bhat, Hans Christian Moxter, and Fernando Diez ACG Worldwide When pharmaceutical manufacturers discover capsules that perform poorly because of brittleness, they often attribute the problem to manufacturing processes or storage conditions. But many other factors can lead to brittle capsules. apsules have come a long way since they were patented in 1834. Today they are one of the most common and pop- ular means of orally administering pharmaceuticals and dietary supplements. Valued at $1.5 billion in 2016, the global market for empty gelatin capsule shells is forecast to increase to $2.21 billion in 2021, a compound annual growth rate of 7.2 percent [1]. As Figure 1 shows, in 2007 only 6 percent of approved drug products containing a new chemical entity used a cap- sule, but in 2015, the percentage tripled. This is because

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