20
January 2017
Tablets & Capsules
Issue focus capsule filling
Gelatin
RXL gelatin for two-piece capsules and
softgels reduces amount of crosslinking to
improve dissolution and extend shelf-life,
even at high temperatures and humidity.
Suitable for pharmaceuticals and dietary
supplements, gelatin contains no non-
gelatin additives, which can speed QbD-
based product development because it
reduces possibility that new capsule prod-
ucts will fail stability testing. Gelatin can
also reduce need for Tier 2 dissolution
testing and allows you to formulate softgel
fills with pH as high as 8.5. It is available
from bovine or porcine sources. Com-
pany also offers product development and
reformulation support, process advice,
and regulatory guidance.
Gelita, Sergeant Bluff, IA.
Tel. 712 943 5516
www.gelita.com
Capsule filler
Practica dosator-type capsule filler performs single-product dosing of powders, gran-
ules, and pellets. High-accuracy machine operates at low, medium, or high speed
and produces as many as 100,000 capsules per hour. Pellets are dosed with vacuum
assistance; air jet removes excess pellets, enabling you to fill micro-tablets and deli-
cate coated pellets. After capsules are filled, closed, and discharged, compressed air
and suction clean upper and lower bushings. In addition to standard rotary bowl,
company offers vacuum bowl that pre-compacts fine powders. Optional statistical
checkweighing unit combines with self-adjusting dosing head to ensure weight
accuracy.
IMA North America, Leominster, MA.
Tel. 978 537 8534
www.ima-na.com
Capsule filling services
CDMO supports solid dosage products from early-stage formulation through com-
mercialization. Company fills pharmaceutical or dietary supplement powders into
capsule sizes 000 through 5. It also offers over-encapsulation for manufacturing clin-
ical trial materials. Company operates four sites in Montreal, which also offer variety
of commercial manufacturing, packaging, and serialization options.
Ropack Pharma Solutions, Montréal, PQ, Canada.
Tel. 514 353 7000
www.ropack.com
Enteric capsule
Vcaps Enteric capsule provides inherent enteric protection, delaying release without
using functional coating. With no need to prepare, apply, or validate coatings, capsule
simplifies formulation, development, scaleup, and validation. It also reduces develop-
ment time by 6 months through Phase I and by more than 12 months through Phase
III when formulating with acid-sensitive or gastric-irritating compounds. Capsule deliv-
ers many API types and complies with relevant EP, JP, and USP monographs.
Capsugel, Morristown, NJ.
Tel. 862 242 1700
www.capsugel.com