Issue link: https://www.e-digitaleditions.com/i/1163217
30 September 2019 Tablets & Capsules I n today's pharmaceutical landscape there's a dearth of true blockbuster drugs on the horizon, driving many com- panies to place more emphasis on developing combination and niche products. Drug product development personnel have begun to shift away from legacy powder- and bead-filling of hard-shell capsules toward more complex drug delivery systems, including hard-shell capsules filled with liquids or a fixed combination of liquids and other materials such as pellets, beads, microtablets, or capsules. Solubilizing active pharmaceutical ingredients (APIs) in an appropriate vehicle and adding one or more different dos- This article describes the benefits of liquid-filled hard-shell capsules for combination products, discusses the factors to consider during capsule selection, and provides examples of currently marketed combinations and potential candidates for development. Developing combination drug products using liquid-filled hard-shell capsules Justin Kalafat ACG North America capsules