Issue link: https://www.e-digitaleditions.com/i/1163217
36 September 2019 Tablets & Capsules P harmaceutical and nutraceutical production personnel often struggle to achieve the same tablet hardness as that achieved during R&D and sometimes fail to reach even the specified minimum hardness. While the tablets may be fine in all other aspects, such as weight, thickness, and disintegration time, they are softer than those produced during R&D. Insufficient tablet hardness can lead to defects such as lamination and erosion of some tablets during coating. Often, the problem is related to blending, This article is the second in a two-part series discussing how blending practices can influence tablet compression. In part one (July 2019), the author explained how percolation of air entrapped in a formulation during blending influences mate- rial flow. Part two discusses how blending can influence tablet hardness. Blending and tablet compression: Tablet hardness Fred A. Rowley Solid Dosage Training mixing and blending