Issue link: https://www.e-digitaleditions.com/i/1233462
24 April 2020 Tablets & Capsules Wenming Zeng, Denise Doerflein Fulk, Lana L. Woshnak, and Susan Hazels Mitmesser Pharmavite Effects of different cleaning agents on the appearance, smell, and taste of softgel capsules softgels T This article describes a study investigating the effects of different cleaning agents on the appearance, smell, and taste of softgel cap- sules in a multivitamin-mineral-fish oil product. The study com- pares the effectiveness of mineral oil, medium chain triglycerides (MCT) oil, mineral oil with 1 percent lecithin, and MCT oil with 1 percent lecithin at cleaning residue from softgel capsules. he final step before packaging a softgel product is to clean and polish the capsules to remove any residue [1]. This residue may include lubricants such as mineral oil or MCT oil and leaked fill materials such as OTC or prescription drug substances, vitamins, minerals, glycerin, fish oil, and soybean oil. Some manufacturers clean soft- gels using ethanol-sprayed cloth towels and then polish them using dry cloth towels. Ethanol is volatile, however, and can have negative impacts on the environment and human health and safety.