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16 September 2020 Tablets & Capsules References 1. Ezgi Ilhan, Timucin Ugurlu, and Oya Kerimo- glu. "Mini tablets: A short review-revision." Peertechz J Med Chem Res. July 2017. 3(1):012-022. DOI: 10.17352/ ojc.000007. 2. American Pharmacists Association. Tableting specifi- cation manual, seventh edition. Available at: https://ebusi- ness.pharmacist.com/PersonifyEbusiness/Shop-APhA/ Product-Details/productId/115810. 3. Metropolitan Computing Corporation. Pharmaceu- tical process scale-up. Michael Levin, ed. Boca Raton, FL: CRC Press (Marcel-Dekker), pages 228-231. Todd D. Martin is senior tooling engineer at Wilson Tool International (800 467 8444, www.wilsontool.com). Wilson Tool's tableting division provides compression tooling, includ- ing standard punches and dies, accessories, and custom- designed tool solutions, to the pharmaceutical, nutraceutical, industrial compression, confectionary, and other industries. resulting tip-force rating. As a result, smaller head flats may be helpful for microtip tooling. In addition, friction and inertia between the punch head and the pressure roll can cause the punch to deflect angularly in the turret guideway. The clearance between the guideway and the punch barrel determines the amount of angular deflection. Worn guideways increase eccentricity, which reduces the amount of force you can safely apply to microtip tooling. A close-fitting set of guideways, with no excessive wear, may be helpful when running microtip tooling on a tablet press. The upper and lower punch barrel diam- eters should match unless the lower turret's guideways are smaller in diameter. In other words, a B lower punch barrel with a 0.745-inch diameter isn't recommended for microtip tooling unless the specific press requires a lower barrel of that diameter. Most don't. Torque For shaped minitablets and for multitip applications, the interaction between the punch head and the pres- sure roll can also apply a torque to the lower punch tips. To protect the lower punch tips from torque in this situ- ation, consider using a rotating punch head to decrease the loads applied to the punch tips. However, rotating heads increase the cost and complexity of the tooling, so you should select them only when necessary for a particular application. T&C Figure 3 Side load distribution during compression on lower punch tip