Issue link: https://www.e-digitaleditions.com/i/1287521
44 September 2020 Tablets & Capsules N Jose Acosta, Sofia Pareja, Dahgna Paez, Jefferson Castro, and Freddy Barrios Procaps Jorge Ropero Universidad del Atlántico Using near-infrared spectroscopy and chemometric modeling to simultaneously determine ibuprofen and caffeine concentration in softgels analytical techniques This article summarizes a method for rapid and accurate deter- mination of API concentration in the fill of soft gelatin capsules with little or no sample preparation. Applying chemometric models to near-infrared spectrum data allows scientists to pre- dict the API content in samples from the manufacturing process and the final product. ear-infrared spectroscopy (NIR) has become more popular in the pharmaceutical industry in recent years as a rapid analytical tool for identifying raw materials and monitoring manufacturing processes. NIR allows opti- mal handling of specific and relevant information and is non-destructive and non-invasive, giving it an advan- tage over conventional pharmacopoeial techniques, such as high-performance liquid chromatography (HPLC),