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12 January/February 2021 Tablets & Capsules Barry Fox Mendel Company Capsule filling for research and development or small-scale production capsule filling T This article discusses important factors to consider when select- ing a capsule filler for research and development (R&D) or small-scale production. he two-piece hard-shell gelatin capsule is a tried and true technology for oral delivery of solid dosage com- pounds, but capsule filling processes still require R&D testing to ensure accurate filling. Many active pharma- ceutical ingredients (APIs) are difficult to obtain, so capsule filling testing methods must be frugal to get as much test data as possible from limited amounts of API. Therefore, it is imperative to find small, research- scale equipment that can be scaled up for production