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adding the data collected from the friability and disinte- gration tests. In this case, the coprocessed excipient yielded tablets of acceptable tensile strength over a wide range of compaction forces. Most of these tablets disinte- grated within the required 30 seconds, but those made at 346 and 416 MPa did not. Considering that people prefer ODMTs to disintegrate quickly, the optimal compaction pressure for these 3-mm flat-faced tablets is between 139 and 208 MPa. In that range, hardness is between 1 and 1.5 MPa; friability weight loss is between 0.57 and 0.65 percent; and disintegration time is between 5 and 10 sec- onds. Although not shown here, the ejection and detach- ment forces measured by the powder compaction ana- lyzer were within acceptable limits. Other work The most exciting data we are currently evaluating relates to the in-die dynamics of the compaction process 32 May 2016 Tablets & Capsules Figure 8 TTFS measurements made using 10-kg load cell versus 500-kg load cell b. 500-kg load cell a. 10-kg load cell 2.5 2 1.5 1 0.5 0 5 4 3 2 1 0 Fracture load (kg) Fracture load (kg) Displacement (mm) Displacement (mm) 8 6 4 2 0 Fracture load (kg) Displacement (mm) 75 kg 150 kg 250 kg 2.5 2 1.5 1 0.5 0 4 3 2 1 0 Fracture load (kg) Fracture load (kg) Displacement (mm) Displacement (mm) 8 6 4 2 0 Fracture load (kg) Displacement (mm) 75 kg 150 kg 250 kg