Issue link: https://www.e-digitaleditions.com/i/678483
© 2016 Capsugel Belgium NV All rights reserved. Not all capsules are created equal. Vcaps ® Plus Capsules The new standard in HPMC capsules: Immediate release in-vivo performance bioequivalent to gelatin and consistent dissolution across changing pH and ionic strength. Vcaps ® Plus capsules can optimize capsule disintegration for pharmaceutical products with the ability to release contents independent of pH and ionic strength of the test media. And a new in-vivo study demonstrates that Vcaps Plus capsules are equivalent to gelatin in terms of human pharmacokinetics profile. Finally, a superior specialty polymer capsule with proven gelatin-like performance without cross-linking potential, Vcaps Plus is the new capsule standard with benefits of narrow weight variability, impressive resistance to heat and humidity, and validated manufacturing experience. By reducing variability, Vcaps Plus capsules are quickly becoming a powerful new tool to reduce timelines in drug product development. Contact us at 800-845-6973 for our full technical package and samples for your development review. New in-vivo results comparing Vcaps Plus HPMC Capsules and gelatin capsules demonstrate bioequivalency of HPMC in multiple dissolution profiles. % Caffeine dissolved Time in minutes 0 10 20 30 40 50 60 70 80 90 100 pH 1.2 USP pH 6.8 USP pH 6.8 JP2 Simulated milk fluid pH 1.2 – 2 g KCI/L pH 1.2 – 9 g KCI/L 0 3 6 9 12 15 18 21 24 27 30 35 40 45 50 55 60 75 In-vitro dissolution of caffeine in Vcaps Plus capsules True pH and Ionic Media Independence Mean Plasma Acetaminophen Concentration (ng/mL) Nominal Hours (hrs) Post Dose 0 0 2 4 6 8 10 12 1000 2000 3000 4000 5000 6000 7000 8000 Gelatin Capsules Vcaps Plus Capsules Molecule = Acetaminophen Human cross-over study in 24 subjects Mean in-vivo acetaminophen plasma concentration profiles over 12 hours. Proven Bioequivalence to Gelatin Read the full report at VcapsPlus.com.