Issue link: https://www.e-digitaleditions.com/i/819216
cylindrical tablets [1]. This problem arises because flashing introduces errors in the measured thickness. Consequently, when tablet density is calculated from the tablet's weight and volume, the result will be erro- neous. Such errors can then propagate to subsequent analyses of tablet compressibility, which would make characterizations of the tablet's true density, plasticity, and powder consolidation behavior erroneous as well. In some cases, measurements of compression parame- ters—including mean yield pressure derived from a Heckel analysis—could be off by nearly a hundredfold. Without proper correction, wrong conclusions may be Tablets & Capsules May 2017 31 Figure 2 Comparison of friability data obtained using an expedited method and the USP method [2] MCC - Expedited method MCC - USP method DCPD - Expedited method DCPD - USP method Figure 1 Tablet flashing on a sodium iodide tablet compressed at 200 megapascals [1] a. Top view c.Top view of same tablet after flashing removed using sandpaper d. Side view of same tablet after flashing removed using sandpaper b. Side view Reproduced with permission Reproduced with permission a. Plastic: microcrystalline cellulose b. Brittle: dibasic calcium phosphate 15 10 1 0.1 0.01 7 10 20 30 40 50 Compaction pressure (MPa) Tablet friability (%) 10 5 2.5 1 0.8 50 100 150 200 250 300 Compaction pressure (MPa) Tablet friability (%)