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liquid-filled hard capsule for per-oral administration. Additionally, the pre-concentrate can be layered onto multi-particulate systems and then filled into hard capsules. Additionally, lipid-based excipients are being employed in a variety of new areas of drug delivery, ranging from spray-congealing for solid oral dosage forms to applications of nano-structured lipid carriers for the noninvasive delivery of macromolecules. The versatility and functionality of today's lipid excipients provides formulators with numerous options and capabilities to address and overcome many delivery and performance challenges. While there remains a need to further understand the physical and chemical stabil- ity of various ANI classes within lipid-based systems, it is clear that lipids will play an expanding and pivotal role in enhancing the bioavailability of poorly soluble ANIs. T&C References 1. Gasior, Maciej et al. Neuroprotective and disease- modifying effects of the ketogenic diet. Behav Pharmacol. Sep: 17(5-6). 2006, 431-439. 2. Kesi, Shannon et al. Effects of exogenous ketone sup- plementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague-Dawley rats. Nutr Metab. Feb 4 (13:9). 2016, 1-16. 3. Paoli, A et al. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr. Jun 26 (67). 2013, 789-796. 4. Wankhade, Vikrant et al. Self-microemulsifying nutraceutical and drug delivery systems. Int J Pharm Sci Nano. Jul-Sep 7 (3). 2014, 2520-2528. 5. Pouton, C et al. Lipid formulations for oral administra- tion of drugs: non-emulsifying, self-emulsifying, and "self- microemulsifying", drug delivery systems. Eur J Pharm Sci. 22 Suppl 2. 2000, S93-S98. 6. Prajapati, H et al. In vitro dispersion test that could serve as a predictive method for assessing performance of lipid-based drug delivery systems. J. Excipients and Food Chem. 4 (4). 2013, 111-125. 7. Agrawal, Anuj G. et al. Formulation development and in vitro hepatoprotective activity of self nanoemulsifying drug delivery system of antioxidant coenzyme Q10. Arch Pharm Res. Dec. 2014, 1-16. 8. Julianto, T et al. Improved bioavailability of Vitamin E with a self-emulsifying formulation. Int J Pharm. 200. 2000, 53-57. 9. Sanyog, J. et al. Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: Implications for drug-induced cardiotoxicity and nephro- toxicity. Free Radic Biol Med. 65. 2013, 117-130. John K. Tillotson, RPh, PhD, is pharmaceutical technical business director at Abitec, 501 West 1st Avenue, Columbus, OH 43215. Tel: 614 429 6464. Email: jtillotson@abiteccorp.com. His research areas include functional lipids, SEDDS development, and direct- compression tabletting. 16 July 2017 Tablets & Capsules