18 January 2019 Tablets & Capsules
R
ecently, a Phase I immediate-release solid oral dosage
formulation of a pro-drug in gelatin capsules failed to
completely dissolve during a three-month accelerated
stability study. Scientists at Metrics Contract Services
were assigned the task of identifying why the product
failed and resolving the issue.
This article describes a study conducted to determine the
cause of poor dissolution in a three-month accelerated stabil-
ity study of a Phase I immediate-release pro-drug gelatin
capsule product.
Crosslinking in gelatin capsules
Jerry Mizell
Steven Genovese
Jerry Neal
Metrics Contract Services
capsule filling
