Issue link: https://www.e-digitaleditions.com/i/1163217
34 September 2019 Tablets & Capsules compared to that of their pure forms [8]. With both applications, manufacturers should assess whether con- sumers would benefit from combining these two common ingredients in liquid form with other nutritional ingredi- ents. Familiarity has also increased with regard to the self-emulsifying nutraceutical delivery system (SENDS), which uses the same type of equipment as that used by the pharmaceutical industry, as shown in Figure 3. Pharmaceutical companies design combination prod- ucts containing liquids to add value to their current prod- ucts. This can be as simple as combining an immedi- ate-release liquid with a delayed-release bead, or in the nutraceutical niche, combining a prebiotic and a probi- otic. Within these applications, formulators can modify dissolution release profiles to benefit patients. Placing a delayed-release capsule inside a larger immediate-release liquid-filled capsule is also possible. Table 3 lists various active ingredient candidates for filling combination products. These include liquids with pellets, liquids with tablets, and liquids with capsules, all Domperidone maleate + Omeprazole DR pellets Domperidone maleate + Rabeprazole DR pellets Vitamin A, D, E, + B complex pellets Ibuprofen + Pseudoephedrine and CPM pellets Nifedipine SR + Atenolol IR Alprazolam SR + Sertraline hydrochloride IR Atorvastatin + Aspirin enteric-coated tablet Clopidogrel + Aspirin enteric-coated tablet Atenolol + Amlodipine Losartan potassium + Amlodipine Atenolol + Hydrochlorothiazide Lisinopril + Hydrochlorothiazide Losartan potassium + Hydrochlorothiazide Losartan potassium + Ramipril capsules Vitamin A, E, + Vitamin C capsule Prebiotic + Probiotic Artesunate + Amodiaquine Artemether + Lumefantrine Arterolane + Piperaquine phosphate DR = delayed-release CPM = California pellet mill SR = sustained-release IR = immediate-release Table 3 Combination product candidates Allendale, New Jersey Óä£ÈÓnÓääÊUÊÜÜÜ°À>iiÀÕðV `Ài°*iÌÀVJÀ>iiÀÕðV For 35 YEARS the pharmaceutical industry has relied upon ÀBiÀ to de-dust, de-burr and convey tablets with the highest efficiency. To learn more about how to *,"6 the EFFICIENCY of your tableting lines contact Kraemer U.S. Tablet de-dusting solutions from the Global Leader