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Tablets & Capsules March 2020 29 grams and provides easy scale up of production parameters for cosmetic and functional film coating, includ- ing controlled-release applications. A KKE 1700 capsule checkweigher enhances the company's existing capsule-filling capacity by provid- ing precise gravimetric weighing of up to 102,000 capsules per hour. A Mycromix lab-scale high-shear granulator handles batch sizes from 0.1 to 3.5 kilograms. "Parsolex had a clear plan to target certain areas of the market, focusing on where their experi- ence lies," says Simon Cashmore, business development manager for than doubling the company's tablet- ing capacity and allowing for greater flexibility, improved yields, and faster changeover times. The press features versatile options, such as integrated die technology and the ability to combine B and D tooling stations in a single turret, along with an advanced data acquisition system for measuring and collecting a wide range of com- pression data. " The flexibilit y of their tablet presses makes them ideal for R&D to medium-sized production batches," says Chang. A Solidlab 2 drum coater han- dles batch sizes from 0.8 to 18 kilo- warehousing to more than 80 pallet locations, leveraging a CAD-designed vertical racking layout to optimize material and work flows. The expanded facility will fea- ture all the prominent process tech- nologies for cGMP manufacture of solid oral dosage forms for clinical trial material and commercial drug products. The company selected pro- cessing and packaging equipment supplier Syntegon Pharma Tech- nology (formerly Bosch Packaging Technology) to provide much of the new equipment for the expansion. "We conducted an extensive dil- igence exercise on equipment sup- pliers, exploring topics of expertise, capabilities, technologies, and ser- vice arrangements," explains Chang. "Ultimately, we selected Syntegon due to their reputation for quality, advancements in pharmaceutical manufacturing technologies, breadth and depth of expertise, and cooper- ative and collaborative approach to a partnering relationship." Expanded manufacturing capabilities The new Syntegon equipment in- cludes granulation, fluid-bed coating and drying, tableting, drum coating, and capsule weight checking technol- ogies. This equipment was selected to complement the company's exist- ing capabilities and provide a diverse range of solid dosage technologies for a range of manufacturing programs. "We're excited to partner with Syntegon to offer our clients access to the latest solid dosage technol- ogy innovations," says Chang. "This access enhances our capability to work on even more complicated and diverse issues that are challenging our clients today." A Pilotmix high-shear mixer/gran- ulator and Pilotlab fluid-bed system provide high-shear granulation and fluid-bed spray granulation, coating, and drying capabilities. The units are configured as an integrated sys- tem, allowing for enclosed, automatic vacuum transfer of material from the mixer to the fluid bed. A TPR 200 tablet press produces up to 230,000 tablets per hour, more Photo 2: The dedicated tablet compression suite features a TPR 200 tablet press with an IBC lift for closed product transfer.