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Tablets & Capsules May 2015 35 References 1. Doelker, E. et al. Comparative compaction properties of various MCC types and generic products. Drug Dev. Ind. Pharm., 19: 2399- 2471, 1993. 2. Hwang, R., and Peck, G.R. A systematic evaluation of the com- pression and tablet characteristics of various types of microcrystalline cel- lulose. Pharm. Technol., 24: 112-132, 2001. 3. Schindler, B., Zeleznik, J., and Renak, J. Sodium stearyl fumarate: An effective tablet lubricant to avoid slippery situations. JRS Pharma. AAPS Annual meeting poster presen- tation, Nashville, 2008. Figure 1 Compaction force vs. hardness of SMCC compacts lubricated with MgSt SMCC – 0.5% MgSt @ 5 min blend SMCC – 1% MgSt @ 5 min blend SMCC – 0.5% MgSt @ 20 min blend SMCC – 2% MgSt @ 5 min blend SMCC – 1% MgSt @ 20 min blend SMCC – 2% MgSt @ 20 min blend Hardness (N) Compression force (kN) 0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00 16.00 18.00 250.00 200.00 150.00 100.00 50.00 0.00 Figure 2 Compaction force vs. hardness of SMCC and MCC compacts lubricated with MgSt SMCC MgSt w/20% CPM – 5 min blend SMCC MgSt w/20% CPM – 20 min blend MCC MgSt w/20% CPM – 5 min blend MCC MgSt w/20% CPM – 20 min blend Hardness (N) Compression force (kN) 0 10 20 30 40 50 60 70 100 90 80 70 60 50 40 30 20 10 0 Coming in July Focus: Excipients & Formulation Special Sections: • Tooling • Mixers & Blenders Issue also includes "Spotlight on Nutraceuticals" Show Coverage includes: Pack Expo Preview (Sept. 28-30)