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36 May 2015 Tablets & Capsules 4. Guo, M., and Augsburger, L.L. Potential application of silicified microcrystalline cellulose in direct- fill formulations for automatic cap- sule-filling machines. Pharm Dev. Technol. 8(1):47-59, 2003. 5. Muzíková, J., and Nováková, P. A study of the properties of com- pacts from silicified microcrystalline celluloses. Drug Dev. Ind. Pharm. 33(7):775-81, 2007. David Schaible is a principal scientist and manages R&D and Louis Mejias is scien- tist II at JRS Pharma, 2981 NY-22, Pat- terson, NY 12563. Tel. 845 878 3414. Website: www.jrs.de. Schaible specializes in API-excipient co-processing and devel- opment of high-performance excipients; he has been awarded several patents for devel- opment of co-processed excipients. Figure 3 Compaction force vs. hardness of SMCC-MCC compacts lubricated with SSF SMCC SSF w/20% CPM – 5 min blend SMCC SSF w/20% CPM – 20 min blend MCC SSF w/20% CPM – 5 min blend MCC SSF w/20% CPM – 20 min blend Hardness (N) Compression force (kN) 0.00 10.00 20.00 30.00 40.00 50.00 60.00 350.00 300.00 250.00 200.00 150.00 100.00 50.00 0.00 Figure 4 Compaction force vs. hardness of SMCC-SSF tablets and MCC-MgSt tablets SMCC SSF w/20% CPM – 5 min blend SMCC SSF w/20% CPM – 20 min blend MCC MgSt w/20% CPM – 5 min blend MCC MgSt w/20% CPM – 20 min blend Hardness (N) Compression force (kN) 0 10 20 30 40 50 60 350 300 250 200 150 100 50 0 Start your free subscription at our website. Tablets & Capsules digital edition is available. free worldwide!! www.tabletscapsules.com