Tablets & Capsules

TC0515

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Tablets & Capsules May 2015 37 A survey of what's available particle size: reduction, separation & analysis Particle size analyzer SALD-2300 laser-diffraction particle size analyzer allows you to test wet and dry samples simply by changing flow cells. With batch cell, sampler with flow-through cell, and cyclone injection unit, you can analyze wet or dry samples of 0.1 parts-per-million to 20 percent particle concentration range. Highly concentrated samples can be measured without dilu- tion, preventing dispersion or agglomeration. Instrument's range is 17 nanometers to 2,500 microns. It uses one sensor to detect side-scattered light and five others to detect back- scattered light in real time at minimum of 1-second intervals. Wing Sensor II has 78 concentric detector elements that can acquire data with multiple peaks. Software automatically cal- culates appropriate refractive index based on method used to reproduce light-intensity distribution. You can analyze data from various angles using statistical processing, time-series analysis, and 3D graphs Operation log stores measurement data and instrument contamination status. Shimadzu Scientific Instruments, Columbia, MD. Tel. 800 477 1227 www.ssi.shimadzu.com Bead mills DeltaVita series bead mills reduce particles to 200 nanometers or less, increasing surface area and improving dissolution and bioavailability of poorly soluble APIs. Better bioavailability reduces amount of API required, production costs, and risk of side effects. GMP-compliant units produce batches of 15 milli- liters to 4,000 liters. Laboratory mills accept grinding chambers in range of sizes, use grinding media of 0.05 to 2 millimeters, and separate media from product using centrifugal force. Com- pany supplies test and qualification documentation and FAT, IQ, OQ, and PQ validation. Clean-in-place and sterilize-in-place systems are optional for pilot- and production-scale mills. Data recording and formulation management are also available. Netzsch Premier Technologies, Exton, PA. Tel. 800 676 6455 www.netzsch.com/gd Powder flow tester PFT powder flow tester requires only 43 cubic centimeters of powder to determine flow function, time consolidation, and wall friction. Data indicates flow index, arching dimen- sion, rat-hole diameter, hopper half angle, gravity chute angle, and bulk density curve. Benchtop unit includes Powder Flow Pro software and is easy to operate. Company can per- form IQ/OQ/PQ certification for you or you can self-certify using company's IQ/OQ/PQ document with step-by-step instructions and calibrated reference powder. Self-certifica- tion kit is available worldwide. Brookfield Engineering, Middleboro, MA. Tel. 800 628 8139 www.brookfieldengineering.com

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