Issue link: https://www.e-digitaleditions.com/i/626800
L 10 January 2016 Tablets & Capsules liquid-filled capsules Formulating with liquids: Two-piece or softgel capsules? Angie Roberson Qualicaps When developing a new drug product, you eventually must decide on the dosage form. In the realm of solid dosage, a tablet is often the default choice. But if the API is to be delivered as a liquid, you'll have to decide between a two-piece and a softgel capsule. This article summarizes the factors that influence that decision. iquid fills can deliver active pharmaceutical ingredients (APIs) that are otherwise difficult or impossible to deliver via other solid dosage forms. That has led many research and development scientists to reappraise their library of compounds to identify promising substances. If any were rejected solely because their poor stability and bioavailabil- ity posed formulation challenges, then liquid delivery could offer a solution because it would improve bioavailability and absorption. It's even better if the API exists in liquid form because then it's already solubilized and readily dis-