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faster they will disintegrate. At lab scale, regular HPC powders usually require 5 minutes of granulation, but fine and superfine HPC powders require only 3 minutes to optimize the properties of the tablets pro- duced from the granulation. In gen- eral, the finer powder sizes provide better results, and the SSL-SFP grade requires the shortest granulation time and water volume to produce tablets with superior properties. Fluid-bed granulation. When granulating using a fluid-bed proces- sor, the HPC is added as a binder solution, and an 8 percent aqueous solution of 40-mesh L, SL, or SSL HPC is typical [2]. At lab scale, the spray rate of the binder solution is usually around 5 milliliters per minute. The smallest granules are obtained by granulating with the SSL grade, and the granules become coarser as the HPC's viscosity increases. When the granules are used to manufacture tablets, there is a tendency for the granules made from lower-viscosity HPCs to produce harder tablets with a shorter disinte- gration time and faster drug release. However, any low-viscosity HPC can be used in fluid-bed processes; it depends on what release profile and what combination of tablet proper- ties you seek. Direct compression. Small-particle powders are more compressible and produce harder tablets when directly compressed compared to large-particle powders [3]. In the case of HPC, SSL- SFP additions can be just 3 percent and still perform comparably or better in IR tablets than other binders used at 15 percent, including microcrystalline cellulose (MCC) PH-101, various grades of PVP-vinyl acetate (VA), low- substituted HPC, pre-gelatinized starch, and even our own SL-Fine Powder HPC. At one-fifth the usage rate of other dry-binder excipients, the SSL-SFP grade may enable you to reduce the size of direct-compression tablets, increase their active load, and improve binding of poorly compress- ible actives. Orally disintegrating tablets. These fast dissolving tablets, known as ODTs, help children, the elderly, and others who have difficulty swallowing traditional tablets [4, 5]. MCC is com- monly used in ODTs, but replacing a small portion of the MCC with SSL- SFP HPC can result in a superior tablet. In fact, substituting a 1 to 3 per- cent concentration of SSL-SFP can increase ODT tablet hardness, decrease friability and, when formu- lated with appropriate disintegrants, provide an acceptable disintegration time. The substitution often resolves capping issues, too. Furthermore, the addition of HPC improves the stabil- ity of an ODT's critical tablet proper- ties—particularly friability—compared to tablets without HPC. Film forming Orally disintegrating film. It is sometimes difficult to reach a good balance of tablet hardness and quick disintegration with ODTs, but orally disintegrating films (ODFs) offer an 38 October 2013 Tablets & Capsules The new platform excipient for tablets, sachets and more • first rate filler-binder properties due to excellent compressibility • fast and slow disintegrating tablets (chewables, effervescents, suckables, FDDTs …) • ideal in sachets for direct oral application or dry suspensions • outstanding flow and mixing properties • high dilution potential and high content uniformity • very low hygroscopicity and excellent stability • GMO-free and non-animal origin The Smart Excipient BENEO-Palatinit GmbH · Phone: +49 621 421-150 · info @ galenIQ.com · www.galenIQ.com 7 – 9 October 2014 Paris Nord Villepinte, France hall 5, booth R79 Come and visit us at