Issue link: https://www.e-digitaleditions.com/i/1138630
22 July 2019 Tablets & Capsules Issue focus excipients & formulation Bioavailability-enhancing excipients Company develops and manufactures lipid-based excipients to enhance the bio- availability of poorly water-soluble and poorly permeable APIs. Offerings include Capmul bioavailability enhancers, which are medium-chain mono- and diglycerides and propylene glycol esters that act as solubilizers and emulsifiers in oral drug delivery systems. Functional lipid excipients are a suitable starting point for formulating BCS Class II and IV (poorly water-soluble) and BCS Class III and IV (poorly permeable) molecules. Company's lipid-based drug delivery systems may be formulated as liquid or semi-solid formulations. Abitec, Columbus, OH 614 429 6464 www.abiteccorp.com Starch-based excipient StarTab starch-based excipient for direct compression is composed of unique par- ticle sizes and shapes and provides excellent flow and compressibility on high- speed tablet presses. Excipient allows formulation scientists to simplify tablet for- mulation and manufacture, while providing enhanced stability for moisture-sensi- tive APIs. Starch-based product is accepted by international regulatory bodies, allowing for easy adoption by formulators and manufacturers. Colorcon, Harleysville, PA 215 256 7700 www.colorcon.com Gelatin for softgels Company offers many gelatin types to achieve different release profiles, including RXL gelatin that reduces cross-linking and speeds release of fill. Company's EC gelatin allows for one-step production of clear enteric capsules using existing equipment. Enteric gelatin reduces production time and cost by eliminating the need to coat fresh softgels with an acid-insoluble film coating, which is opaque and less desired by consumers. It also minimizes the effects of ingesting fish oil and other omega-3 fatty acids, including fishy burps and aftertastes. Capsules comply with USP dissolution parameters. Gelita USA, Sergeant Bluff, IA 800 223 9244 www.gelita.com Titanium-dioxide-free film coating SheffCoat TF titanium-dioxide-free film coating matches the pleasing aesthetics of a white or colored tablet normally associated with TiO 2 -based film coatings. Coating can be applied using conventional mixing and film-coating equipment, requiring minimal changes to process conditions and film coat weights. Product can be used as a traditional white coating or customized with synthetic or natural pigments to create visually appealing colored tablets. Kerry, Beloit, WI 608 363 1200 www.kerry.com