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30 July 2019 Tablets & Capsules W hen lecturing at pharmaceutical R&D departments and colleges of pharmacy, I am often asked why one batch of a tablet formulation will compress differently from the previous batches. Often, the answer has to do with air trapped in the formulation during blending. Variations in the amount of air entrapped in a powder can greatly influence how the powder flows in a tablet press. Most process development engineers have probably noticed that the height of some finished powder blends This article is the first in a two-part series discussing how blending practices can influence tablet compression. The second part will appear in Tablets & Capsules' September issue. Blending and tablet compression: Air percolation Fred A. Rowley Solid Dosage Training mixing and blending